The match will also see the return to the Bok side of Damian Willemse, who missed out last year because of injury.
Vincent Tshituka will make his Test debut when the Springboks face Italy in the first of two Tests at Loftus Versfeld in Pretoria on Saturday.
Tshituka, who played for the Boks in the non-Test against the Barbarians in Cape Town last Saturday, is the only uncapped player in the matchday-23.
In the key selections, Damian Willemse is at fullback, where he will play his first Test since 2023 after missing out completely last season due to injury, Handre Pollard will be at flyhalf, while Morne van den Berg will be his scrumhalf, after also facing the Baabaas last weekend.
Jasper Wiese is at No 8 in a loose trio that is without Siya Kolisi, who is injured. Jesse Kriel will continue to captain the side, as he did against the Barbarians. He will become the 67th Bok captain.
Wilco Louw will pack down at tighthead prop, while on the bench Faf de KLerk and Willie le Roux will be the two backs replacements in a six-two split.
Bok team: 15 Damian Willemse, Cheslin Kolbe, Jesse Kriel (capt), Damian de Allende, Kurt-Lee Arendse, Handre Pollard, Morne van den Berg, Jasper Wiese, Vincent Tshituka, Marco van Staden, Lood de Jager, Eben Etzebeth, Wilco Louw, Malcolm Marx, Ox Nche. Bench: Bongi Mbonambi, Jan-Hendrik Wessels, Vincent Koch, RG Snyman, Franco Mostert, Kwagga Smith, Faf de Klerk, Willie le Roux
